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We studied the relation of serum granulocyte colony-stimulating factor (G-CSF) and leukocytosis during exercise. Eleven healthy subjects were given graded exercise by treadmill. Complete blood cell co...unts. G-CSF, plasma adrenaline (Ad), plasma noradrenaline (NA), lactate, blood sugar (BS), serum sodium (Na), serum potassium (K) were determined before and during exercise. Heart rate (HR) and blood pressure (BP) were monitored during exercise. The results were as follows: 1) White blood cells (WBC) markedly increased without the significant change of G-CSF. Moderate exercise induced the increase of granulocyte and lymphocyte number while heavy exercise caused the higher rate of increased in lymphocyte than in granulocyte. 2) Hematocrit (Ht) showed significant increase during exercise although both red blood cells (RBC) and hemoglobine (Hb) hardly changed. The rate of increase in Ht was lower than that of WBC. 3) Exercise induced the increase of catecholamine, resulting in the increases of HR, BP and K. These results show that exercise-induced leukocytosis is independent on G-CSF. It is suggested that exercise induced catecholamine causes the increase of both β2-adrenoreceptor density and adrenergic responsiveness of leukocyte, resulting in leukocytosis followed by the increase of lymphocyte.show more
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