九州大学農学研究院環境農学部門サスティナブル資源科学講座森林圏環境資源科学研究室
Laboratory of Systematic Forest and Forest Products Sciences, Division of Sustainable Bioresources Science, Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University
九州大学農学研究院環境農学部門サスティナブル資源科学講座森林圏環境資源科学研究室
Laboratory of Systematic Forest and Forest Products Sciences, Division of Sustainable Bioresources Science, Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University
九州大学農学研究院環境農学部門サスティナブル資源科学講座森林圏環境資源科学研究室
Laboratory of Systematic Forest and Forest Products Sciences, Division of Sustainable Bioresources Science, Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University
所属機関
所属機関名
近畿大学産業理工学部生物環境化学科
Department of Biological and Environmental Chemistry, Kindai University
Allergies are caused by abnormalities in the immune tolerance mechanism mediated by regulatory T cells (Treg), and the metabolites of the dietary fibers are important for the oral immune tolerance mechanism. Inulin acts as a dietary fiber and changes the intestinal microflora, which is expected to regulate the immune tolerance mechanism and to be a new treatment for allergies. In this study, we conducted a randomized, placebo-controlled, double-blind, parallel-group study in 49 adult subjects (13 males and 36 females) with various allergic symptoms to examine the effects of the supplementation of Fuji FF, a enzymatic synthesized soluble inulin, on allergic symptoms and mucosal immunity. Subjects took Fuji FF or placebo for 4 weeks, and changes in immune function were verified by two questionnaires and saliva tests. Though no clear improvements were found from Dermatology Life Quality Index (DLQI) and the saliva tests, the result of Japan Allergic Rhinitis Standard Quality of Life Questionnaire (JRQLQ) suggested the effectiveness in the suppression of allergic rhinitis symptoms. Our study indicates that Fuji FF can be applied as a treatment for nasal allergy-like symptoms.
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