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＜departmental bulletin paper＞
Recovery Pattern of Behavioral Responses in Female Zebrafish to Short–term Amitriptyline Hydrochloride Exposure

Creator
Creator Name
LI, Lixia
Affiliation
Affiliation Name
Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
Creator Name
DONG, Kejun
Affiliation
Affiliation Name
Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
Creator Name
CHEN, Chen
Affiliation
Affiliation Name
Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
Creator Name
CHEN, Kun
Affiliation
Affiliation Name
Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
Creator Name
SHI, Yanhong
Affiliation
Affiliation Name
Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
Creator Name
QIU, Xuchun
Affiliation
Affiliation Name
Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
Affiliation
Affiliation Name
Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou University of Science and Technology
Author PID
K001666
40363329
Creator Name
SHIMASAKI, Yohei
島崎, 洋平
シマサキ, ヨウヘイ
Affiliation
Affiliation Name
Laboratory of Marine Environmental Science, Faculty of Agriculture, Kyushu University
九州大学大学院農学研究院
Author PID
K001575
70176874
Creator Name
OSHIMA, Yuji
大嶋, 雄治
オオシマ, ユウジ
Affiliation
Affiliation Name
Laboratory of Marine Environmental Science, Faculty of Agriculture, Kyushu University
九州大学大学院農学研究院
Language
English
Publisher
Faculty of Agriculture, Kyushu University
九州大学大学院農学研究院
Date
2022-09
Source Title
Journal of the Faculty of Agriculture, Kyushu University
Vol
67
Issue
2
First Page
181
Last Page
187
Publication Type
Version of Record
Access Rights
open access
Crossref DOI
https://doi.org/10.5109/4797825

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Details

PISSN
0023-6152
NCID
AA00697606
Record ID
4797825
Subject Terms
Amitriptyline
Zebrafish
Neurotransmitter levels
Behavior
Recovery
Notes
Amitriptyline (AMI) is a tricyclic antidepressant (TCA) that has been widely used to treat depression. The widespread use has caused AMI to enter the environmental waters with a maximum concentration of μg/L. However, knowledge of its persistent toxic effects on fish is still limited. Therefore, this study exposed female zebrafish to 10 μg/L of AMI for seven days, followed by a 21–day recovery in AMI–free water. The results showed that AMI could induce persistent or delayed hypoactivity and abnormal social behavior in zebrafish. AMI exposure also significantly altered the brain levels of 5–HT, 5–HIAA, and ACH. Correlation analysis revealed that 5–HT and ACH were negatively correlated with locomotor activity, and 5–HT was also positively correlated with social interaction. Our finding demonstrated that AMI could cause persistent abnormal behavior in zebrafish and alter the brain neurotransmitter levels in zebrafish, suggesting that those long–term impact should not be ignored.
Funding Information
Funder Name
Natural Science Foundation of Jiangsu Province of China
Award Number
BK20191433
Created Date 2022.09.05
Modified Date 2023.03.07

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