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This study focuses on the deposition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-laden droplets in the upper respiratory tract of the human body based on host-cell dynamics (HCD). ...First, the deposition of five particle sizes in the airway was preliminarily obtained by combining and analyzing the results of computational fluid dynamics (CFD) previously studied, and the target cell-limited model was used to roughly predict the variation trend of viral load over time after infection. Then, the initial conditions and parameters in the target cell-limited model were changed to observe the effects on the prediction of viral load. The results showed that the virus-carrying droplets were mainly concentrated in the nasal cavity and throat. The initial susceptible target cells T(0) and other parameters had different effects on the prediction of viral load. Therefore, it is necessary to identify suitable parameters for the dynamic calculation of SARS-CoV-2.続きを見る
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