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Abstract:(E)-N-(3,4-dimethylisoxazol-5-yl)-4-((4-hydroxy-2-oxo-2H-chromen-3-yl)diazenyl)benzene sulfonamide (HDF) was prepared by condensation of 4-hydroxy coumarin and 4-amino-N-(3,4-dimethylisoxazol...-5-yl)benzene sulfonamide (sulphafurazole). The structure of synthesized compound was established using IR, 1H and 13C-NMR spectral analysis. On evaluation of in-vitro anti-herpetic activity of this compound against HSV-1, compound was found able to inhibit viral replication at late stages of infection by inhibiting the replication of HSV-1. This anti herpetic nature of HDF was evidenced by the reduction of specific gene productsβ-(ICP-6) and γ-(ICP-5 and gB) groups in western blotting.続きを見る
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