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Assessment of Initial Chest Computed Tomography Findings and Clinical Features of 151 Patients with COVID-19 Pneumonia of First and Second Waves in Japan
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| Abstract | Introduction : Coronavirus Disease 2019 (COVID-19) has caused serious illness and numerous deaths worldwide. We evaluated the clinical features and initial chest computed tomography (CT) findings of 1...51 patients with COVID-19 pneumonia with the aim of comparison between first and second waves and exploring the factors associating the deterioration of oxygenation status during the clinical course. Methods : We retrospectively enrolled 151 patients with COVID-19 pneumonia, diagnosed by reverse transcription-polymerase chain reaction (RT-PCR) and evaluated their clinical findings and CT imaging characteristics. The extent of pneumonia was evaluated visually and semi-quantitatively by the distribution of ground glass opacity (GGO) as follows : none, localized lesion, ＜25% involvement of the whole lung, ＞ 25% and ＜ 50% involvement and ＞ 50% involvement. We also evaluated the presence of crazy-paving appearance, consolidation, and linear opacity. Results : The visual extent of GGO was positively correlated with shortness of breath, requirement of oxygen therapy at admission, the duration from onset to CT (B6 days), and the presence of a crazy-paving appearance and linear opacity. Most of the localized lesions showed a peripheral and non-segmental distribution. Patients in the second wave had a high rate of infection at dinner party, and generally had mild clinical symptoms. Exacerbation of oxygenation status after admission was significantly associated with age, hypertension, diabetes, higher value of body mass index (BMI), C-reactive protein (CRP), D-dimer, alanine aminotransferase, and a wider distribution of GGO. Conclusion : The extent of GGO reflects the severity of pneumonia. It is also associated with deterioration of oxygenation status after admission.show more |
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| Created Date | 2021.06.09 |
| Modified Date | 2021.06.09 |