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＜journal article＞
Pathogenesis of Atopic Dermatitis 2020
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| Abstract | Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. Excellent clinical efficacy of the anti-interleukin-4 (IL-4) receptor α antibody dupilumab under...pins the pivotal roles of T helper type 2 (Th2) cytokines IL-13 and IL-4 in the pathogenesis of AD. Th2 cells also produce IL-31 which is the most important pruritogenic cytokine in AD. IL-13 and IL-4 downregulate the expression of filaggrin in keratinocytes and exacerbate epidermal barrier dysfunction. Keratinocytes in barrier-disrupted epidermis produce large amounts of thymic stromal lymphopoietin, IL-25 and IL-33, which contribute to Th2 immune deviation via OX40L/OX40 signaling. IL-13 and IL-4 also amplify the IL-31-mediated pruritus. In this review, I summarize recent advances in the pathogenesis of AD.show more |
| Table of Contents | はじめに 1．IL-4RシグナルとAD 2．IL-22 とADの慢性化 3．IL4R シグナルと皮膚バリア障害 4．皮膚バリア障害は表皮細胞によるTSLP，IL-25，IL-33 産生を誘導し，2 型免疫偏移を助長する 5．IL-31，IL-13/IL-4と瘙痒 おわりに |
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| Created Date | 2021.03.22 |
| Modified Date | 2021.03.22 |