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Pathogenesis of Chloracne and Hyperpigmentation in Yusho : Role of Aryl Hydrocarbon Receptor
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| Abstract | Yusho, occurred in 1968, is an intoxication of high concentrations of polychlorinated dibenzofurans and their related compounds. Like other intoxication by dioxin-like compounds, one of the major symp...toms of Yusho is skin symptom such as chloracne and pigmentation. Dioxins exert their major toxicity by binding and activating aryl hydrocarbon receptor (AHR) and subsequent generation of reactive oxygen species (ROS). Sustained and exaggerated AHR activation by dioxins accelerates the keratinization of keratinocytes and converts the sebaceous differentiation of sebocytes to keratinocyte-like differentiation which results in loss of sebocytes and cyst formation of hair follicle, leading to chloracne. AHR activation by dioxins upregulates the melanogenesis of melanocytes, leading to pigmentation. Phytochemical Kampo drugs which inhibit AHR activation and subsequent ROS production are potential treatment for Yusho patients.show more |
| Table of Contents | はじめに 1．AHRシグナルによる酸化ストレスと炎症性サイトカイン産生 2．表皮細胞におけるAHRの生理学的な役割―角化の促進― 3．環境化学汚染物質によるAHR活性化と塩素痤瘡 4．環境化学汚染物質によるAHR活性化と色素沈着 5．環境化学汚染物質によるAHR活性化とその治療対策 おわりに |
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| Created Date | 2021.01.08 |
| Modified Date | 2021.03.03 |