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Development of New Treatment in Pediatric Intractable Disease using Regenerative Medicine : Focusing on Stem Cells from Human Exfoliated Deciduous Teeth
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| Abstract | Regenerative medicine using stem cell can provide new treatment modalities for intractable diseases. Stem cells from human exfoliated deciduous teeth (SHED) share some characteristics of mesenchymal s...tem cells (MSCs), and exhibit self-renewal, multipotency into a variety of mature cells. Recent studies have conducted to evaluate the immunomodulatory effects of SHED, which are considered a feasible cell source for tissue engineering and regenerative medicine. In comparison with other stem cells, SHED have the distinct advantages of minimal risk of oncogenesis and less ethical controversy, and a readily accessible source, easy and minimally invasive collection. SHED have also high stem cell potential such as cell proliferation, multipotency, and immunosuppressive ability even after cryopreservation. Even in adult, we may use wisdom teeth or buried teeth for harvesting dental pulp stem cell. Currently, some companies have been creating a SHED bank for allogenic cell therapy in future. They are also collaborating us for clinical study using autologous SHED. We have been trying to develop new treatments for pediatric intractable diseases, such as, intestinal motility disorders (allied disorders of Hirschsprungʼs disease, liver failure and enzyme-deficient diseases, and severe congenital diaphragmatic hernia, using cell therapy and tissue engineering technology including SHED.show more |
| Table of Contents | はじめに 1．脱落乳歯歯髄幹細胞（SHED） 2．ヒルシュスプルング病類縁疾患Hypoganglionosisに対するSHED移植 3．小児の肝移植の現状 4．肝移植の問題点 5．肝細胞移植 6．ミニ肝臓移植 7．大きな肝臓の作成 8．再生医療を用いた横隔膜パッチ 9．同種SHED移植に向けて まとめと展望show more |
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| Created Date | 2021.01.08 |
| Modified Date | 2021.03.03 |