Quantitative Proteomic Analysis of Nile Tilapia Brain Following Sub–Chronically Exposed to Toxic Cyanobacteria Microcystis aeruginosa - Collections

＜departmental bulletin paper＞
Quantitative Proteomic Analysis of Nile Tilapia Brain Following Sub–Chronically Exposed to Toxic Cyanobacteria Microcystis aeruginosa

Creator	Creator Name XU, Hai Affiliation Affiliation Name Institute of Environmental Health and Ecological Security, School of Environment and Safety Engineering, Jiangsu University
	Creator Name DING, Yuling Affiliation Affiliation Name Institute of Environmental Health and Ecological Security, School of Environment and Safety Engineering, Jiangsu University
	Creator Name QIU, Xuchun Affiliation Affiliation Name Institute of Environmental Health and Ecological Security, School of Environment and Safety Engineering, Jiangsu University
	Author PID K001666 Creator Name SHIMASAKI, Yohei 島崎, 洋平シマサキ, ヨウヘイ
	Author PID K001575 Creator Name OSHIMA, Yuji 大嶋, 雄治オオシマ, ユウジ
Language	English
Publisher	Faculty of Agriculture, Kyushu University
Publisher	九州大学大学院農学研究院
Date	2020-09
Source Title	Journal of the Faculty of Agriculture, Kyushu University
Vol	65
Issue	2
First Page	283
Last Page	288
Publication Type	Version of Record
Access Rights	open access
Crossref DOI	https://doi.org/10.5109/4103892

File	FileType	Size	Views	Description
p283	pdf	660 KB	417

PISSN	0023-6152
NCID	AA00697606
Record ID	4103892
Subject Terms	Microcystis
	Proteomics
	Brain
	Nile tilapia
Notes	In the present study, we investigated the effects of Microcytis on Nile tilapia brain. Male Nile tilapia were exposed to lyophilized Microcytis aeruginosa for 28 days. An isobaric Tags for Relative and Absolute Quantitation (iTRAQ) approach coupled with nano high–performance liquid chromatography–tandem mass spectrometry (nano HPLC–MS/MS) analysis was employed to detect and identify the differential expressed proteins. A total of 49 proteins were successfully identified and categorized into functional classes that mostly included metabolism, ubiquitin–proteasome, signal transduction and transporting, indicating that Microcytis toxicity in the fish brain is complex and diverse. Our proteomic analyses added new perspective to Microcytis neurotoxicity in aquatic organisms.
Funding Information	Funder Name National Natural Science Foundation of China Award Number 21407066
Created Date	2020.11.06
Modified Date	2022.11.11