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＜journal article＞
Differential Roles of Carboxylated and Uncarboxylated Osteocalcin in Prostate Cancer Growth

Creator
Creator Name
Hayashi, Yoshikazu
ハヤシ, ヨシカズ
Affiliation
Affiliation Name
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University
九州大学大学院歯学研究院口腔細胞工学分野
Affiliation
Affiliation Name
Section of Oral and Maxillofacial Oncology, Faculty of Dental Science, Kyushu University
九州大学大学院歯学研究院口腔顎顔面病態学講座顎顔面腫瘍制御学分野
Author PID
K004153
0000-0002-6483-3074
Creator Name
Kawakubo, Tomoyo
川久保, 友世
カワクボ, トモヨ
Creator Alternative Name
Yasukochi, Tomoyo
安河内, 友世
ヤスコウチ, トモヨ
Affiliation
Affiliation Name
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University
九州大学大学院歯学研究院口腔細胞工学分野
Affiliation
Affiliation Name
Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University
福岡大学薬学部
Author PID
K005189
Creator Name
Mizokami, Akiko
溝上, 顕子
ミゾカミ, アキコ
Affiliation
Affiliation Name
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University
九州大学大学院歯学研究院口腔細胞工学分野
Affiliation
Affiliation Name
OBT Research Center, Faculty of Dental Science, Kyushu University
九州大学大学院歯学研究院附属オーラルヘルス・ブレインヘルス・トータルヘルス研究センター
Author PID
70304813
Creator Name
Takeuchi, Hiroshi
竹内, 弘
タケウチ, ヒロシ
Affiliation
Affiliation Name
Division of Applied Pharmacology, Kyushu Dental University
九州歯科大学歯学部歯学科応用薬理学分野
Author PID
K001027
Creator Name
Nakamura, Seiji
中村, 誠司
ナカムラ, セイジ
Affiliation
Affiliation Name
Section of Oral and Maxillofacial Oncology, Faculty of Dental Science, Kyushu University
九州大学大学院歯学研究院
Author PID
60136471
Creator Name
Hirata, Masato
平田, 雅人
ヒラタ, マサト
Affiliation
Affiliation Name
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University
九州大学大学院歯学研究院口腔細胞工学分野
Language
English
Publisher
Ivyspring International Publisher
Date
2016-07-18
Source Title
Journal of Cancer
Vol
7
Issue
12
First Page
1605
Last Page
1609
Publication Type
Version of Record
Access Rights
open access
Rights
(C) Ivyspring International Publisher
Rights
Creative Commons Attribution-NonCommercial 4.0 International
Related DOI
isIdenticalTo
https://doi.org/10.7150/jca.15523
Related DOI
Related URI
Related URI
Related HDL
Abstract Serum levels of osteocalcin (OC), a bone matrix non-collagenous protein secreted by osteoblasts, are correlated with pathological bone remodeling such as the bone metastasis of cancer, as well as phys...iological bone turnover. The pathological roles in prostate cancer growth of the two existing types of serum OC, γ-carboxylated (GlaOC) and lower- (or un-) carboxylated (GluOC), have not yet been discriminatively examined. In the present study, we demonstrate that normal prostate epithelial cell growth was promoted by both types of OC, while growth of cancer cells in the prostate was accelerated by GlaOC but suppressed by GluOC. We suggest that OC regulates prostate cancer growth depending on the γ-carboxylation, in part by triggering reduced phosphorylation of receptor tyrosine kinases.show more

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Details

EISSN
1837-9664
Record ID
4071702
Peer-Reviewed
Refereed
Related PubMed ID
27698897
Subject Terms
osteocalcin
prostate cancer
Funding Information
Funder Name
日本学術振興会
Japan Society for the Promotion of Science (JSPS)
Award Number
24229009
Award Title
骨・腸・代謝連関シグナルの解明と性差の明確化
Analysis of the functional interaction among bone, gut and energy metabolism with a special reference to gender difference
Funder Name
日本学術振興会
Japan Society for the Promotion of Science (JSPS)
Award Number
26861554
Award Title
インクレチンによる小腸粘膜や膵臓の恒常性維持に関する研究
Homeostasis in glycoilipid metabolism-related organs maintained by incretin
Funder Name
日本学術振興会
Japan Society for the Promotion of Science (JSPS)
Award Number
16K11496
Award Title
組織特異的 non-coding RNA が制御する癌の病態形成メカニズムの解析
Analysis of cancer pathogenesis regulated by tissue-specific non-coding RNA
Funder Name
日本学術振興会
Japan Society for the Promotion of Science (JSPS)
Award Number
26861553
Award Title
オステオカルシンの内分泌作用に関する研究
Endocrine functions of osteocalcin
Funder Name
日本学術振興会
Japan Society for the Promotion of Science (JSPS)
Award Number
16K20421
Award Title
オステオカルシンによる膵α細胞のグルカゴンからGLP-1への変換機構の解明
Glucagon-GLP-1 conversion by osteocalcin in pancreatic alpha cells
Created Date 2020.10.14
Modified Date 2020.11.09

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