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This study was carried out in order to clarify the factors influencing the "outgrowing" of childhood asthma and the development of asthmatic attack. Two hundred and seventysix (3.4%) of the 8055 fresh...men students of Kyushu University from 1972 to 1975, answered that they had suffered from bronchial asthma or had an asthmatic history in childhood. One hundred and eight students received our medical examination. Of these students, 102 were divided into 2 groups: Group I included 57 subjects who had asthma in childhood and then became asymptomatic for 3 years or more, Group II, 45 asthmatic patients. Six students were omitted because of no physical symptoms or history of asthma. The results are summarized as follows. 1. The number of subjects who had suffered from asthma or had asthmatic history, had been increasing every year, from 2.6.% in 1972 to 4.2% in 1975. Most patients developed bronchial asthma in the period from 2 to 7 years old and the age of cessation was found in the period of adolescence from 11 to 16 years old. 2. Group I and GroupII were similar as to the onset of asthmatic attacks, incidence of other allergic diseases in their past history, present illness and the incidence of asthmatic patients in their family history. 3. Group I and Group II showed similar results in the incidence of positive response to skin tests using house dust, ragweed pollen, candida albicans and polyvalent bacterial vaccine. 4. Serum lgE levels measured by the Radioimmunosorbent test which was performed in 1974 and 1975 were remarkably elevated in Group I and Group II compared to the control group (p＜0.05). The mean levels (upper and lower limit of S.D.) were 481 (1360-170) U/ml in Group I, 931 (3200-264) U/ml in Group II and 220 (386 114) U/ml in the control group, There was no significant statistical difference between Group I and Group II. 6. The mean % FEV1.0 (I.S.D.) was 86.6 (±8.6) % in Group II and 82.5 (±10.4) % in Group II. Each group was within the normal range. But it is suspected that a small and subclinical bronchial obstruction might contineued or induced at the examination in Group II. The threshold amount of acetycholine which was needed to decrease FEV1.0 by more than 15 % was significantly different (p＜0.05) in the 3 groups. The mean (and range of S.D.) of threshold amount was 10300 (25600-3920) μg in Group I, 2560(9640-683)μg in Group II and more than 25000μg in the control group. There was no direct correlation between threshold amounts of acetylcholine and serum lgE levels or anti-house dust reaginic antibody levels in each group. 7. In the Rosenzweig Picture Frustration Study, the asthmatics showed impunitive, ego involved (M) reactions and did not show extrapunitive, ego involved (E) reactions compared to the normal groups. The personality in Group I and Group II was generally similar but that of Group I was closer in personality to the same aged students of the control group. These findings suggest that the "outgrowing" of asthma in childhood may occur without the recovery of atopic constitution and may be related to bronchial sensitivity.show more
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