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| Abstract |
水酸化ポリ塩化ビフェニル(OH-PCBs)は，人体内におけるPCB の主要代謝物である．OH-PCBs は体内でチトクロームP450酵素誘導によりPCBから生成され，油症認定患者の血清から390-1300pg/gの濃度で検出された報告がある．2010年度に183名の油症患者から採取した血液中のOH-PCBs濃度を測定し，これら化合物の濃度を比較した．主要なPCBの代謝物は，4-OH-CB187(N...D-1300 pg/g-wet)，4-OH-CB146 + 3-OH-CB153(8.4-1200 pg/g-wet)，4-OH-CB109(ND-530 pg/g-wet)，4'-OH-CB172(ND-380 pg/g-wet)であり，その合計は36-3800 pg/g-wetであった．また，OH-PCBsとPCB濃度には正の関係が認められたが，OH-PCBsとPCDD/DFsの濃度には有意な関係は認められなかった．
Hydroxylated polychlorinated biphenyls (OH-PCBs) are formed as major metabolites of PCBs by cytochrome P450 enzyme-mediated oxidation. It has been reported that their total concentration in serum samples of Yusho patients ranged from 390 to 1300 pg/g. We measured the concentration of OH-PCBs in blood collected from 183 Yusho patients living in Japan in 2010. The major OH-PCB metabolites were 4-OH-CB187 (ND-1300 pg/g-wet), 4-OH-CB146 + 3-OH-CB153 (8. 4-1200 pg/g-wet), 4-OH-CB109 (ND-530 pg/g-wet) and 4'-OH-CB172 (ND-380 pg/g-wet). The total OH-PCBs ranged from 36 to 3800 pg/g-wet. A positive relationship between the concentrations of OH-PCBs and PCBs was observed, but no significant relationship between the concentrations of OH-PCBs and PCDD/DFs was observed.show more
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