| Abstract |
油症患者のダイオキシン類による人体汚染とその健康影響を把握する目的で，平成16年から22年度の期間に油症患者から採取した血液中PCDDs，PCDFsおよびPCBs濃度の測定を行った．平成16および22年度に油症検診を受診した患者は，それぞれ242および200名で，その中で136名の患者が両年度に受診を行った．平成16 年度に測定した136名の油症患者血液中PCDDs，PCDFsおよびPCBsの各異...性体濃度を平成22年度の測定結果と比較した．その結果，油症患者血液中PCDDs，PCDFsおよびPCBsのほとんどの異性体が，平成16年から22年の期間に濃度減少を示さなかった．しかしながら，油症患者血液中1,2,3,4,6,7,8-heptaCDD，octaCDD，1,2,3,4,7,8-hexaCDF，tetraCB52/69，pentaCB101，octaCB198/201およびoctaCB196/203の濃度は，平成16年度の結果と比べて減少していた．加えて，1,2,3,6,7,8-hexaCDD，2,3,4,7,8-pentaCDFおよび1,2,3,6,7,8-hexaCDFの濃度も減少傾向を示した．
We measured the concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) in blood collected from Yusho patients during medical health examinations performed from 2004 to 2010. Out of the 242 and 200 Yusho patients who received medical health examinations in2004 and 2010, respectively, the concentrations of PCDDs, PCDFs, and PCBs in the blood of 136 patients were measured in both of those years. The concentrations of individual congeners of PCDDs, PCDFs, and PCBs in the blood of these 136 Yusho patients measured in 2004 were compared with those measured in 2010. Among individual congeners of PCDDs, PCDFs, and PCBs, most congeners of these compounds did not significantly decrease from 2004 to 2010. However, the concentrations of 1, 2, 3, 4, 6, 7, 8-heptaCDD, octaCDD, 1, 2, 3, 4, 7, 8-hexaCDF, tetraCB 52/69, pentaCB 101, octaCB 198/201, and octaCB 196/203 in the blood of Yusho patients were significantly decreased from 2004 to 2010. In addition , the concentrations of 1, 2, 3, 6, 7, 8-hexaCDD, 2, 3, 4, 7, 8-pentaCDF, and 1, 2, 3, 6, 7, 8-hexaCDF tended to decrease slightly from 2004 to 2010. These findings suggest that the PCDDs, PCDFs, and PCBs have remained in the blood of Yusho patients for a very long time, with over 40 years having passed since the outbreak of Yusho.show more
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