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| Abstract |
油症患者血液中PCDDs，PCDFsおよびnon-ortho PCBs分析を新しい大量注入装置を装備した高分解能ガスクロマトグラフ/高分解能質量分析法(HRGC/HRMS)を用いて検討した．新しい大量注入装置は胃袋型インサートを備えたLaviStomaシステムとSolvent-cut large-volume injection(SCLV)システムを連結して用いた．この装置を用いて，注入条件を検討...した結果，200µl の試料注入が可能となった．同一の血液を用いて行った従来のSCLV法との比較検討の結果，本法は従来法と同様な結果が得られることが確認された．本法は従来のSCLV法に比べ，血液試料の前処理段階で費やす時間を短縮することができ，PCDDs，PCDFsおよびnon-ortho PCBsの回収率も約20％向上した．
We developed a more effective method to measure the concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and non-ortho-coplanar polychlorinated biphenyls (non-ortho PCBs) in the blood of Yusho patients using high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS) equipped with a newly large-volume injection system. The new injection system linked a LaviStoma system with a unique stomach-shaped inlet liner (SSIL) and a solvent-cut large-volume (SCLV) injection system. This approach made it possible to introduce volumes up to 200µl into the HRGC/HRMS in comparison with the 20µl volume of the previously reported conventional SCLV method. Based on experiments conducted using the same blood sample, the concentrations of PCDDs, PCDFs, and non-ortho PCBs obtained by the developed method showed a close correlation to that by the conventional SCLV method. By improving the injection method, the operation time and labor for the purification procedure from blood could be reduced. Furthermore, the developed method was more effective than the conventional SCLV method for recovery of PCDDs, PCDFs, and non-ortho PCBs.show more
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