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Solution is a liquid dosage form that ensures better bioavailability of drug upon oral administration. In this study an attempt was taken to prepare theophylline solution (20mg/ml) using sodium carbox...y-methylcellulose as a vehicle. Feasibility of Na-CMC as drug vehicle was tested and compared with widely used vehicle water. Effect of different storage conditions on organoleptic and physicochemical properties was tested for a period of three months. Drug potency was found 9-13 mg/ml and 14-16 mg/ml in water and Na-CMC respectively and was consistent with time. Viscosity of the solution was good with easy pourability for both of the vehicles used. Theophylline solution in water showed changes in color after two months. However, no changes in organoleptic properties with CMC-Na as vehicle within the experimental time period irrespective of storage condition. Moreover, good stability of the theophylline solution was seen with Na-CMC at 1% (w/v) concentration.続きを見る
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