To clarify whether DHA-enriched or iodine egg has anti-allergic effect or not, Sprague-Dawley rat were fed with egg yolk powder of these health oriented eggs at the 10% level and the effects on serum immunoglobulin level and immunoglobulin productivity of lymphocytes were examined. Feeding of iodine or DHA-enriched egg powder in creased IgG productivity of spleen lymphocyte and iodine egg powder feeding strongly activated IgM production of the lymphocyte. In mesenteric lymph node lymphocytes, significant enhancement of IgG productivity was observed only in DHA-enriched group, while IgM productivity significantly enhanced in all egg yolk fed groups including normal egg. On the other hand, there was no remarkable effect on IgE productivity in both lymphocytes. These results suggest that immunostimulatory effect via activation of IgG and IgM production has important meaning in these egg yolk powder of health oriented eggs.