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Comparison of the Concentrations of Polychlorinated Dibenzo-p-dioxins, Polychlorinated Dibenzofurans, and Polychlorinated Biphenyls in the Blood of Yusho Patients Measured in 2004 with those Measured in 2014
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| Abstract | We have been measuring the concentrations of PCDDs (polychlorinated dibenzo-p-dioxins), PCDFs (polychlorinated dibenzofurans), and dioxin-like PCBs (polychlorinated biphenyls) in blood collected from ...Yusho patients in medical health examinations since 2002. The present study extends our previous studies by reporting changes in the concentrations of individual congeners of PCDDs, PCDFs, and dioxin-like PCBs in the blood of Yusho patients from 2004 to 2014. Out of 243 and 246 Yusho patients who received medical health examinations in 2004 and 2014, respectively, there were 118 patients in whom the blood concentrations of these dioxin like-compounds were measured in both years. The concentrations of individual congeners of PCDDs, PCDFs, and PCBs in the blood of these 118 Yusho patients measured in 2004 were compared with those measured in 2014. The total toxicity equivalence (TEQ) concentrations of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs in the blood of 118 Yusho patients in 2004 and 2014 were 5.2−533 (mean : 80, median : 52) and 11−545 (mean : 78, median : 73) pg TEQ g-1 lipid, respectively. Among the individual congeners of PCDDs, PCDFs, and dioxin-like PCBs, most congeners did not significantly decrease from 2004 to 2014. Though the concentrations of 1,2,3,6,7,8-hexaCDD, 2,3,4,7,8-pentaCDF, 1,2,3,4,7,8-hexaCDF, and 1,2,3,6,7,8-hexaCDF―all considered characteristic congeners in the blood of Yusho patients― decreased significantly from 2004 to 2014, the decreasing ratios of these congeners tended to decrease slightly. These findings suggest that the half-lives of individual congener concentrations of PCDDs, PCDFs and dioxin-like PCBs in the blood are proving to be long to near infinity in the majority of Yusho patients. 平成16および平成26 年度，その両年度に油症検診を受診した118名の血液中ダイオキシン類濃 度の比較を行い，各異性体の濃度推移を調べた．今回調査した異性体の中で，最も濃度が減少して いたのは1,2,3,4,7,8-hexaCDF で，約30％の濃度低下が認められた．油症の主要原因物質である 2,3,4,7,8-pentaCDF は約10％濃度が減少していた．男女間での比較では，女性の方が高い値を示 したが，10 年間の濃度推移に関しては，男女間での相違は認められなかった．show more |
| Table of Contents | Introduction Materials and Methods Results and Discussion |
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| Created Date | 2019.07.22 |
| Modified Date | 2023.11.21 |