Triose reductone combines with amino compounds to form aminoreductones. In order to prepare them and to elucidate their function, reaction of triose reductone with several nitrogenous compounds was investigated. At first, stability of triose reductone at various pH was examined and it was observed that, similar to ascorbic acid, triose reductone is also stable in acid media, especially in metaphosphoric acid. Then, the reactions of triose reductone with p-aminosalicylic acid, guanine, adenine, hydroxylamine, glucose oxime, galactose oxime, urea and hydroxyurea were investigated. Through the determination of the absorption spectrum and its variation of the reaction mixture and the paper chromatography of the product, the reaction of triose reductone with them was established. In addition, it was indicated that the reaction is dependent on pH, although the condition should be examined in detail, and that some compounds containing NOH group can combine with triose reductone.