エストロゲン

1. One day old White Leghorn male chicks were fed diet, added with 0.2 mg of diethylstilbestrol (DES) alone, or in combination with vigofac (V) 5g, terramycin (Tm) 50 mg, or nitrofurylacrylic acid amide (Z) 100 mg, per Kg of the basal diet, respectively. The effects of these medicals on growth and body components of the chicks were studied on 10, 20, and 30 days after starting of the experiment. 2 . The growth and feed efficiency were not altered by DES feeding. Among the medicals used, combination of DES with Z was the best and promoted the growth about 10 % during 30 days. Liver weight was increased by DES feeding, but variable with the other supplementation. 3. There was not noticeable change in the general composition of liver and breast muscle in each group on each period, except that fat content was decreased in the breast muscle in DES+Z group on 30 th day. The concentration of total N and residual N of serum, and lipid composition of liver and serum were also little affected on 30th day of the test. 4. The concentration of vitamin B_2 and pantothenic acid of liver and breast muscle was little affected in each group on 20th and 30th day of the test. The concentration of niacin of both tissues tended to increase by DES feeding. 5. In the second trial chicks, 30 days old, were fed DES (0.2mgjkg diet) for 30 days, and then they were intramuscularly injected each other day with 0.1 mg of DES for 15 days. The growth was not affected in the DES feeding period, but was depressed about 17%, as compared with the control, in DES injection period. Liver was enlarged. 6. Fat content of the breast muscle was decreased in both treatment. Total N and residual N content of the serum was not altered in the latter. Phopholipids of liver and serum was slightly increased. 7. Concentration of vitamin B_1 and B_2 in liver, breast muscle and serum, and that of pantothenic acid and niacin in liver and muscle was little affected in both DES treatments. Concentration of vitamin A in liver and kidney was variable, but not altered in serum and muscle.