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| Abstract |
Dioxins may have an impact on the human immunological system, which would increase the risk to develop allergic diseases, such as atopic dermatitis. In the present study, we measured serum levels of T...h1- and Th2-favored chemokines in 233 Yusho patients who attended annual medical check-ups from 2006 to 2009 and in 97 control subjects. Serum levels of CCL5, CCL17, and CCL27 in Yusho patients were significantly lower than those in control subjects. In addition, serum levels of some chemokines have weak correlations with blood levels of dioxins in either Yusho patients or control subjects.
ダイオキシン類の慢性毒性の一つとして免疫系 への影響があげられ，近年のアレルギー性疾患の 増加とダイオキシン類による環境汚染との関連が議論されることがある．本研究では，現在でも高い血中ダイオキシン類濃度を有する油症患者を対象に，Th1，Th2 環境で高値を示すケモカインを中心に各種血清ケモカイン濃度を測定し，ダイオキシン類の影響について検討した．show more
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