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A Case of Poisoning in a Man who Drank a Nutrition Supplement Containing Methomyl, A Carbamate Pesticide
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| Abstract | A 50-year-old man was admitted to the emergency room complaining oppression on his chest, sweating and vomiting. He had drunk a 30 ml volume nutrition supplement 60 minutes before. As myosis and decre...ase of serum choline esterase activity were observed on admission examination, poisoning was suspected and toxicological analyses were carried out on the heeltap of the drink. Drug screening by gas chromatography-mass spectrometry (GC/MS) revealed the presence of methomyl and the concentration of methomyl in the heeltap determined by liquid chromatography was 2.1 mg/ml. Methomyl concentrations in the serum and urine were determined after converting methomyl to its oxime form followed by derivatization and GC/MS. Methomyl concentration in the serum collected 6 hours after ingestion was 0.63 ,μg/ml, and that in the urine collected 7-20 hours after ingestion was 0.10 μg/ml. Based on these values and reported data, the amount of methomyl contaminated to the drink was considered to be a toxic dose. 30m1容量の栄養ドリンク剤を飲用した50歳男性が胸苦しさ,発汗,吐き気を訴え急患として搬送された.入院時の検査で縮瞳と血清コリンエステラーゼ活性の低下が認められたため農薬中毒を疑い,飲み残しのドリンク剤と患者の血清および尿について分析を行った.ガスクロマトグラフィー/質量分析(GC/MS)による薬毒物スクリーニングで飲み残し液からカーバメート系農薬メソミルが検出され,その濃度は液体クロマトグラフィーによる定量分析で2.1mg/mlであった.さらに患者の血清および尿中の微量のメソミルをオキシム体に変換後誘導体化することでGC/MSで定量した.飲用から6時間後の血清中メソミル濃度は0.63μg/ml,7～20時間後の尿中濃度は0.10,μg/mlであった.これらの数値は摂取致死量といわれる12～15mg/kg,過去の中毒死の平均血液中濃度25.6μg/mlのいずれよりもかなり低い値であり,メソミルの混入量は中毒レベルであることが判明した.show more |
| Table of Contents | PCDDs PCDFs Dioxins Concentrations in the Blood Yusho Patients |
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| Created Date | 2012.06.04 |
| Modified Date | 2021.07.28 |