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＜departmental bulletin paper＞
Expression Responses of the Complement Components in Zebrafish Organs after Stimulation with Poly I:C, Mimicry of Viral Infection

Creator
Creator Name
Vo, Kha Tam
Affiliation
Affiliation Name
Laboratory of Marine Biochemistry, Division of Marine Biological Chemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University
Author PID
L004763
Creator Name
Tsujikura, Masakazu
辻倉, 正和
Affiliation
Affiliation Name
Laboratory of Marine Biochemistry, Division of Marine Biological Chemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University
九州大学生物資源環境科学府生物機能科学専攻海洋生命化学講座水族生化学研究室
Author PID
K002663
Creator Name
Somamoto, Tomonori
杣元, 智軌
Affiliation
Affiliation Name
Laboratory of Marine Biochemistry, Division of Marine Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
九州大学大学院農学研究院生物機能科学部門海洋生命化学講座水族生化学研究室
Creator Name
Nakano, Miki
中野, 実樹
Affiliation
Affiliation Name
Laboratory of Marine Biochemistry, Division of Marine Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
Language
English
Publisher
Faculty of Agriculture, Kyushu University
九州大学大学院農学研究院
Date
2009-10-29
Source Title
Journal of the Faculty of Agriculture, Kyushu University
Vol
54
Issue
2
First Page
389
Last Page
395
Publication Type
Version of Record
Access Rights
open access
Crossref DOI
https://doi.org/10.5109/16120
Related DOI
Journal of the Faculty of Agriculture, Kyushu University || 54(2) || p389-395
九州大学大学院農学研究院紀要 || 54(2) || p389-395
http://www.agr.kyushu-u.ac.jp/
Related URI
Journal of the Faculty of Agriculture, Kyushu University || 54(2) || p389-395
九州大学大学院農学研究院紀要 || 54(2) || p389-395
http://www.agr.kyushu-u.ac.jp/
Relation
Journal of the Faculty of Agriculture, Kyushu University || 54(2) || p389-395
九州大学大学院農学研究院紀要 || 54(2) || p389-395
http://www.agr.kyushu-u.ac.jp/

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Details

PISSN
0023-6152
NCID
AA00697606
Record ID
16120
Peer-Reviewed
Unrefereed
ISSN
0023-6152
NCID
AA00697606
Notes
Defensive roles of the complement system in fish are largely unknown, although expressions of several complement components have been examined in some teleost species upon bacterial and parasitic infections. To infer possible anti-virus defensive roles of the complement system in teleost, zebrafish were simulated by intraperitoneal injection of poly I: C, a double strand RNA analogue, to mimic viral infection, and expression of 24 complement components and their subunits in the gill, brain, kidney, gut, hepatopancreas, gonad, heart, spleen, and skin were analyzed by reverse-transcription PCR. In normal (unstimulated) fish, the hepatopancreas showed highest expression of most genes tested, and considerable extra hepatic expression was also observed for many complement components. Upon stimulation, the hepatopancreas showed decreased expression of CD11/CD18, B/C2-A3, MASP3, and properdin, while marked up-regulation of several complement component genes was observed in the gill, suggesting an important but unknown role of the gill in host defense against viral infection.
Created Date 2010.01.08
Modified Date 2022.11.11

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