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＜departmental bulletin paper＞
Identification of cDNA Sequences Encoding the Complement Components of Zebrafish (Danio rerio)

Creator
Creator Name
Vo, Kha Tam
Affiliation
Affiliation Name
Laboratory of Marine Biochemistry, Division of Marine Biological Chemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University
Author PID
L004763
Creator Name
Tsujikura, Masakazu
辻倉, 正和
Affiliation
Affiliation Name
Laboratory of Marine Biochemistry, Division of Marine Biological Chemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University
九州大学生物資源環境科学府生物機能科学専攻海洋生命化学講座水族生化学研究室
Author PID
K002663
Creator Name
Somamoto, Tomonori
杣元, 智軌
Affiliation
Affiliation Name
Laboratory of Marine Biochemistry, Division of Marine Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
九州大学大学院農学研究院生物機能科学部門海洋生命化学講座水族生化学研究室
Creator Name
Nakano, Miki
中野, 実樹
Affiliation
Affiliation Name
Laboratory of Marine Biochemistry, Division of Marine Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
Language
English
Publisher
Faculty of Agriculture, Kyushu University
九州大学大学院農学研究院
Date
2009-10-29
Source Title
Journal of the Faculty of Agriculture, Kyushu University
Vol
54
Issue
2
First Page
373
Last Page
387
Publication Type
Version of Record
Access Rights
open access
Crossref DOI
https://doi.org/10.5109/16119
Related DOI
Journal of the Faculty of Agriculture, Kyushu University || 54(2) || p373-387
九州大学大学院農学研究院紀要 || 54(2) || p373-387
http://www.agr.kyushu-u.ac.jp/
Related URI
Journal of the Faculty of Agriculture, Kyushu University || 54(2) || p373-387
九州大学大学院農学研究院紀要 || 54(2) || p373-387
http://www.agr.kyushu-u.ac.jp/
Relation
Journal of the Faculty of Agriculture, Kyushu University || 54(2) || p373-387
九州大学大学院農学研究院紀要 || 54(2) || p373-387
http://www.agr.kyushu-u.ac.jp/

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Details

PISSN
0023-6152
NCID
AA00697606
Record ID
16119
Peer-Reviewed
Unrefereed
Notes
Zebrafish can be utilized for immunological research as a fish model that allows gene targeting, but lacks enough molecular and sequence information on the complement system, a humoral innate immune factor. The present study aimed at identification of all the major complement components at the molecular level with phylogenetic evidence. Complementary DNA sequences encoding C1q, C1r/s, C2 (B/C2-B), C3, C4, C5, C6, C7, C8, C9, factor B (B/C2-A), the mannose-binding lectin (MBL), two MBL-associated serine proteases, properdin, and factor I were identified by cloning from the hepatopancreas and by database mining. As reported for carp and trout, the presence of two distinct isotypes were confirmed for C3, C4, and C7 also in zebrafish, indicating the ancient evolutionary origin of their diversifications in the vertebrate lineage.
Created Date 2010.01.08
Modified Date 2022.11.11

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