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| Abstract |
ドクダミ(Houttuynia cordata)は，抗酸化作用を有する薬草で，糖尿病，肥満，咳や発熱などに対する大衆療法として利用されている．しかし，その抗酸化作用の細胞学的な機序は明らかではない．本研究ではドクダミエキス(Houttuynia cordata extract ; HCE)の人表皮細胞への影響を検討した．我々は，HCEが表皮細胞内でaryl hydrocarbon receptor... (AHR)およびnuclear factor E2‒related factor 2を活性化し，その下流の抗酸化酵素であるNAD(P)H:quinone oxidoreductase 1 の発現を亢進させることを明らかにした．実際に，HCEはtumor necrosis factor a やbenzo(a)pyrene によるreactive oxygen species (ROS)産生を抑制した．さらに，HCEは表皮のバリア機能維持に関与するフィラグリンの発現もAHR依存性に亢進させた．HCEはROS産生が関与する光老化や表皮バリア破壊を伴う皮膚疾患の治療に有用であるかもしれない．
The plant Houttuynia cordata, which is called "dokudami" in Japanese, is known as a potent antioxidant herb that has been traditionally consumed as a folk medicine for various ailments, such as diabetes, obesity, cough, fever and skin diseases, in Asia. However, its antioxidant mechanism remains largely unknown. In the present study, we investigated the effects of Houttuynia cordata extract (HCE) on human keratinocytes. HCE activated aryl hydrocarbon receptor (AHR) and nuclear factor E2-related factor 2, with subsequent induction of the antioxidative enzyme NAD(P)H:quinone oxidoreductase 1 gene. HCE inhibited the generation of reactive oxygen species (ROS) in keratinocytes stimulated with tumor necrosis factor a or benzo(a)pyrene. Moreover, HCE upregulated the gene expression of filaggrin, an essential skin barrier protein, in an AHR-dependent manner. HCE may be beneficial for treating ROS-related photoaging and barrier-disrupted skin conditions.show more
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