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Amyloid fibril formation is associated with various amyloidoses, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Despite the numerous studies on the inhibition of am...yloid formation, the prevention and treatment of a majority of amyloid-related disorders are still challenging. In this study, we investigated the effects of various plant extracts on amyloid formation of α-synuclein. We found that the extracts from Eucalyptus gunnii are able to inhibit amyloid formation, and to disaggregate preformed fibrils, in vitro. The extract itself did not lead to cell damage. In the extract, miquelianin, which is a glycosylated form of quercetin and has been detected in the plasma and the brain, was identified and assessed to have a moderate inhibitory activity, compared to the effects of ellagic acid and quercetin, which are strong inhibitors for amyloid formation. The properties of miquelianin provide insights into the mechanisms controlling the assembly of α-synuclein in the brain.
α-シヌクレインのアミロイド形成に対する様々な植物抽出物の効果について検討した。その結果、ユーカリの一種であるEucalyptus gunniiの抽出物がin vitroでアミロイド形成を阻害し、生成した線維を脱凝集させた。抽出物自身は細胞毒性を示さなかった。抽出物中ではクエルセチンのグリコシル化体で血漿や脳で検出されるミクリアニンが、アミロイド形成の強い阻害剤であるエラグ酸やクエルセチンと比較して中程度の阻害活性を示した。続きを見る
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Mendeley出力
