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Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of membrane proteins that bind sialic acids, most of which possess cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. G...lycoligands capable of modulating Siglec-mediated responses therefore have potential as therapeutic agents for immune-related diseases. Herein, we synthesized linear and cyclic glycopolymers that multivalently present sialic acid ligands targeting Siglec-E, which is highly expressed on murine macrophages, and evaluated the effect of polymer topology on Siglec-mediated signal suppression. Although no significant difference was observed between the two polymer architectures, the glycopolymers suppressed NF-κB signaling more effectively than the monomeric sialic acid ligand.続きを見る
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