Mendeley出力
＜学術雑誌論文＞
Dynamic contrast-enhanced MRI of oral squamous cell carcinoma: a preliminary study of the correlations between quantitative parameters and the clinical stage
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| 概要 | Objective: To probe the utility of dynamic contrast-enhanced MRI (DCE-MRI) parameters in assessing the clinical characteristics of oral squamous cell carcinoma. Methods: A total of 85 tumours were in...cluded. We applied the Tofts and Kermode model for the DCE-MRI data and obtained three dependent parameters: the influx forward volume transfer constant into the extravascular extracellular space (EES) from the plasma (K^<trans>), the fractional volume of EES per unit volume of tissue (v_e) and the fractional volume of plasma (v _p). We evaluated the correlations between these parameters and the clinical stages. Results: The T stage showed a negative correlation with the K^<trans> (r = −0.2272; p = 0.0365), but it did not show a significant correlation with the other parameters. The N stage showed a negative correlation with K^<trans> (r = −0.1948; p = 0.0404), and there were significant differences between N1 and N2+3 (0.119 ± 0.027 vs 0.096 ± 0.023 min^<−1>; p = 0.0198) and between N0 and N2+3 (0.114 ± 0.29 vs 0.096 ± 0.023 min^<−1>; p = 0.0288). Conclusion: A decrease in the K^<trans> at the primary site was found in advanced N stage cases, which might indicate that the hypoxic status cause a high possibility of the metastasis. Advances in knowledge: A decrease in the K^<trans> at the primary site suggested the high possibility of an advanced N stage.続きを見る |
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| 登録日 | 2024.08.08 |
| 更新日 | 2024.08.08 |