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＜学術雑誌論文＞
フット気道副交感神経節ニューロンにおけるニコチン性アセチルコリン受容体応答のハイドロコルチゾンによる抑制
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| 概要 | The effect of hydrocortison on neurons acutely isolated from the rat airway parasympathetic ganglia was investigated by using nystatin perforated-patch recording configuration under the voltage-clamp ...conditions. Acetylcholine (ACh) evoked inward currents in a concentration-dependent manner with a half maximum effective concentration (EC_50) of3.3×10^-5 Mat a holding potential of -50 m V. The ACh response was mimicked by nicotine, and it was inhibited by both mecamylamine and hexamethonium. a-Bungarotoxin had no effect on the ACh response. Hydrocortisone concentration-dependently inhibited the current induced by 3x10^-5 M ACh with a half maximum inhibitory concentration (IC_50of 2.1×10^-4 M. The effect of hydrocortisone was voltage-independent. Hydrocortisone suppressed the maximum response of the A Ch concentration-response curve, indicating that the inhibitory action of hydrocortisone on the nicotinic ACh response is non-competitive.続きを見る |
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| 登録日 | 2024.07.25 |
| 更新日 | 2025.06.20 |