School adaptation refers to the emotions and cognitions that arise from the relationship between an individual and the school environment. It is a subjective state of adaptation. Individuals with high Sensory-Processing Sensitivity (SPS), which is a difference in how the brain processes sensory information, are sensitive to small stimuli and may have difficulty functioning at work or home due to this sensitivity. This study examined the impact of SPS on students’ subjective school adaptation. The results revealed that SPS affects aspects of college students’ sense of school adaptation, suggesting that those with high SPS may be more likely to feel inferior. While SPS has a negative impact on school adaptability, it also has a positive impact. The results indicate that students with high SPS are more likely to feel inferior at universities. It is important to focus on individual differences, such as the degree and characteristics of individual sensitivity, rather than just whether students are Highly Sensitive Persons.