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＜博士論文＞
ssRNA刺激によって臍帯血（CB）NK細胞からのIFN－γ産生は強力に誘導される
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| 論文調査委員 | |
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| 概要 | Natural killer (NK) cells play important roles in the innate immunity against viral infections. Although newborn infants are more susceptible to severe and recurrent viral infections than adults, the ...precise role of NK cells in the innate immunity against viral infections during neonatal period is not known. To clarify the functional characteristics of cord blood (CB) NK cells, we examined the capacity of CB NK cells to produce IFN-γ in response to the Toll-like receptor (TLR) ligands. We found that NK cells produced a large amount of IFN-γ by the stimulation with ssRNA, a TLR8 ligand, in the presence of IL-2, INF-γ and monocytes. Surprisingly, CB NK cells produced higher amount of IFN-γ than adult peripheral blood (APB) NK cells in this condition. IL-12 produced from monocytes by the stimulation with ssRNA was indispensable for the production of IFN-γ by NK cells. NK cells in cooperation with other innate immune cells may play more important role during the neonatal period than in adults in the host defense against viral infections by high capacity of IFN-γ production to compensate immature acquired immunity.続きを見る |
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med2453
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264 KB | 597 | 本文 | |
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med2453_abstract
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128 KB | 150 | 要旨 |
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| 登録日 | 2013.07.12 |
| 更新日 | 2023.12.08 |