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＜博士論文＞
脂肪細胞Complement factor Bは脂肪細胞の成熟を促進する
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| 概要 | OBJECTIVES:It is well-known that the complement system plays an essential role in host immunity. Observational studies have indicated that complement system-related molecules such as complement factor... B (CfB) and other components are correlated with obesity and/or insulin resistance parameters. In this study, we investigated the role of adipocyte-derived CfB in adipose tissue metabolism. METHODS:We investigated the expression level of complement system-related genes in adipocytes. To understand the role of CfB in adipocyte, we performed Cfb overexpression in 3T3-L1 preadipocytes and generated adipocyte-specific Cfb transgenic mice. RESULTS:Cfb expression was markedly enhanced in 3T3-L1 adipocytes co-cultured with macrophages following endotoxin stimulation. In Cfb-overexpressing cells, the expression of adipocyte differentiation/maturation-related genes encoding peroxisome proliferator-activated receptor γ (Pparγ), adipocyte Protein 2 and perilipin was significantly enhanced. Cfb transgenic mice showed a marked increase in the expression of genes encoding Pparγ, perilipin, sterol regulatory element-binding protein 1 c, and Cd36 in the subcutaneous adipose tissue. CONCLUSIONS:CfB plays a crucial role in late-phase of adipocyte differentiation and subsequent lipid droplet formation.続きを見る |
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1.86 MB | 1,075 | 本文 | |
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213 KB | 318 | 審査結果要旨 |
詳細
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| 登録日 | 2018.05.30 |
| 更新日 | 2020.01.31 |