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The expression of p16I^<INK4a> has been reported to induce cell cycle arrest and cellular senescence.We recently demonstrated that p16I^<INK4a> expression is an integral part of the pathogenesis of po...rokeratosis. In this study, we further examined the p16I^<INK4a> expression in squamous cell carcinoma (SCC) arising from disseminated porokeratosis. p16I^<INK4a>-expressing keratinocytes were detected in the porokeratotic epidermis and atypical keratinocytes in the SCC in situ developed from porokeratosis. The expression of p16INK4a was also detected in the invasive SCC cells ; however, it was eventually lost in the tumoral nests. These results suggest that the aberrant expression of p16I^<INK4a> in affected keratinocytes may be related to the pro-oncogenic nature of porokeratosis. Its expression may be lost by subsequent tumor progression続きを見る
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Mendeley出力
p176