Mendeley出力
＜図書＞
Drug-drug interactions
| 責任表示 | edited by A. David Rodrigues |
|---|---|
| シリーズ | Drugs and the pharmaceutical sciences ; v. 179 |
| データ種別 | 図書 |
| 版 | 2nd ed |
| 出版情報 | New York, N.Y. : Informa Healthcare , c2008 |
| 本文言語 | 英語 |
| 大きさ | xi, 744 p. : ill. ; 24 cm |
| 概要 | Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives. Thorough...y updated, this second edition reflects the significant advances and includes extensive new material on: key interplay between transporters and enzymes in drug metabolism and drug interactions, the integral role of pharmacogenetics in metabolism-based drug-drug interactions, in vivo - in vitro correlations (reversible, mechanism-based inhibition, induction), in silico approaches enabling structure-activity and structure-function studies, high-throughput screening and GLP methods for evaluating drug interactions in vitro, the use of transgenic animal models to evaluate drug interactions. Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information. Book jacket.続きを見る |
| 目次 | Introducing pharmacokinetic and pharmacodynamic concepts / Malcolm Rowland In vitro enzyme kinetics applied to drug-metabolizing enzymes / Kenneth R. Korzekwa Human cytochromes P450 and their role in metabolism-based drug-drug interactions / Stephen E. Clarke and Barry C. Jones UDP-glucuronosyltransferases / Rory P. Remmel, Jin Zhou, and Upendra A. Argikar Drug-drug interactions involving the membrane transport process / Hiroyuki Kusuhara and Yuichi Sugiyama In vitro models for studying induction of cytochrome P450 enzymes / Jose M. Silva and Deborah A. Nicoll-Griffith In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs (reaction phenotyping) with emphasis on cytochrome P450 / Brian W. Ogilvie ... [et al.] The role of P-glycoprotein in drug disposition: significance to drug development / Matthew D. Troutman ... [et al.] Cytochrome P450 protein modeling and ligand docking / K. Anton Feenstra, Chris de Graaf, and Nico P.E. Vermeulen Role of the gut mucosa in metabolically based drug-drug interactions / Kenneth E. Thummel, Danny D. Shen, and Nina Isoherannen Mechanism-based inhibition of human cytochromes P450: in vitro kinetics and in vitro-in vivo correlations / Xin Zhang, David R. Jones, and Stephen D. Hall Transporter-mediated drug interactions: molecular mechanisms and clinical implications / Jiunn H. Lin Metabolism and transport drug interaction database: a web-based research and analysis tool / Houda Hachad, Isabelle Ragueneau-Majlessi, and ReneÌ H. Levy In vivo probes for studying induction and inhibition of cytochrome P450 enzymes in humans / Grant R. Wilkinson Drug-drug interactions: clinical perspective / David J. Greenblatt and Lisa L. von Moltke An integrated approach to assessing drug-drug interactions: a regulatory perspective / Shiew-Mei Huang, Lawrence J. Lesko, and Robert Temple Drug-drug interactions: toxicological perspectives / Sidney D. Nelson Drug-drug interactions: marketing perspectives / Kevin J. Petty and Jose M. Vega.続きを見る |
所蔵情報
| 状態 | 巻次 | 所蔵場所 | 請求記号 | 刷年 | 文庫名称 | 資料番号 | コメント | 予約・取寄 | 複写申込 | 自動書庫 |
|---|---|---|---|---|---|---|---|---|---|---|
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医学図 1F 開架図書 | QV 38/D 794/2008 | 2008 |
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042212009010178 | Global 30 |
書誌詳細
| 一般注記 | Includes bibliographical references and index |
|---|---|
| 著者標目 | Rodrigues, A. David |
| 件 名 | LCSH:Drug interactions LCSH:Pharmacokinetics MESH:Drug Interactions MESH:Pharmaceutical Preparations -- metabolism 全ての件名で検索 MESH:Pharmacokinetics |
| 分 類 | LCC:RM302 NLM:W1 NLM:QV 38 DC22:615/.7045 |
| 書誌ID | 1001411295 |
| ISBN | 9780849375934 |
| NCID | BB0070430X |
| 巻冊次 | ISBN:9780849375934 ; XISBN:0849375932 |
| 登録日 | 2010.01.21 |
| 更新日 | 2010.01.21 |