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<図書>
Pharmacokinetic-pharmacodynamic modeling and simulation

責任表示 Peter L. Bonate
データ種別 図書
出版情報 New York, N.Y. : Springer , c2006
本文言語 英語
大きさ xii, 387 p. : ill. ; 29 cm
概要 This book presents both the art and science behind pharmacokinetic-pharmacodynamic modeling. Using a building-block approach, the author starts from linear and nonlinear models at the individual level...and proceeds to develop more complex linear and nonlinear mixed effects models at the population level, with particular emphasis on showing the interrelationships between the various model types. The theory behind the methods are illustrated using real data drawn from the literature and from the author's own experiences in drug development. Data are analyzed using a variety of software, including SAS, WinNonlin, SAAM II, and NONMEM. A key component of the book is to show how models are accepted and rejected, ultimately leading to a useful and informative model that can be utilized using computer simulation to answer "what-if" questions. Book jacket.続きを見る

所蔵情報



薬 薬物動態 薬//薬物動態 2006
044212008000026

書誌詳細

一般注記 Includes bibliographical references
著者標目 Bonate, Peter L.
件 名 LCSH:Pharmacokinetics -- Mathematical models  全ての件名で検索
LCSH:Drugs -- Physiological effect -- Mathematical models  全ての件名で検索
分 類 LCC:RM301.5
DC22:615/.7
書誌ID 1001350925
ISBN 9780387271972
NCID BA87314668
巻冊次 ISBN:9780387271972
登録日 2009.09.18
更新日 2009.09.18

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