<図書>
Pharmacokinetic-pharmacodynamic modeling and simulation
責任表示 | Peter L. Bonate |
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データ種別 | 図書 |
出版情報 | New York, N.Y. : Springer , c2006 |
本文言語 | 英語 |
大きさ | xii, 387 p. : ill. ; 29 cm |
概要 | This book presents both the art and science behind pharmacokinetic-pharmacodynamic modeling. Using a building-block approach, the author starts from linear and nonlinear models at the individual level...and proceeds to develop more complex linear and nonlinear mixed effects models at the population level, with particular emphasis on showing the interrelationships between the various model types. The theory behind the methods are illustrated using real data drawn from the literature and from the author's own experiences in drug development. Data are analyzed using a variety of software, including SAS, WinNonlin, SAAM II, and NONMEM. A key component of the book is to show how models are accepted and rejected, ultimately leading to a useful and informative model that can be utilized using computer simulation to answer "what-if" questions. Book jacket.続きを見る |
所蔵情報
状態 | 巻次 | 所蔵場所 | 請求記号 | 刷年 | 文庫名称 | 資料番号 | コメント | 予約・取寄 | 複写申込 | 自動書庫 |
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薬 薬物動態 | 薬//薬物動態 | 2006 |
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044212008000026 |
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書誌詳細
一般注記 | Includes bibliographical references |
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著者標目 | Bonate, Peter L. |
件 名 | LCSH:Pharmacokinetics -- Mathematical models
全ての件名で検索
LCSH:Drugs -- Physiological effect -- Mathematical models 全ての件名で検索 |
分 類 | LCC:RM301.5 DC22:615/.7 |
書誌ID | 1001350925 |
ISBN | 9780387271972 |
NCID | BA87314668 |
巻冊次 | ISBN:9780387271972 |
登録日 | 2009.09.18 |
更新日 | 2009.09.18 |