Mendeley出力
＜図書＞
What's wrong with my mouse? : behavioral phenotyping of transgenic and knockout mice
| 責任表示 | Jacqueline N. Crawley |
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| データ種別 | 図書 |
| 版 | 2nd ed |
| 出版情報 | Hoboken, N.J. : John Wiley , c2007 |
| 本文言語 | 英語 |
| 大きさ | xvi, 523 p. : ill. ; 26 cm |
| 概要 | When the 1990 edition appeared, about 500 papers had been published on behavioral neurosciences' new tool of mice with targeted gene mutations as models of human genetic disorders. Incorporating the e...ponentially expanded research literature, Crawley (chief, Laboratory of Behavioral Neuroscience, National Institutes of Heath) summarizes topics including the consequences of dysfunctional genes, genetic variations, genes that render organisms susceptible to disease or are protective, and environmental shaping of genotypes. A new chapter reviews applications of these genetic models in Alzheimer's and other neurodegenerative diseases. She also discusses strategies for behavioral phenotyping, sequencing of tests for hypothesis testing, new bioinfromatics tools, and future directions (e.g., studying tissue-specific as vs. "global" mutations). Annotation ©2007 Book News, Inc., Portland, OR (booknews.com) 続きを見る |
| 目次 | Designer mice : scope and sourcebooks Of unicorns and chimeras : how to generate a transgenic or knockout mouse for behavioral phenotyping General health : give your mouse a physical Motor functions : open field, holeboard, rotarod, balance, grip, circadian activity, circling, stereotypy, ataxic gait, seizures Sensory abilities : olfaction, vision, hearing, taste, touch, nociception Learning and memory : Morris swim task, spatial mazes, cued and contextual conditioning, conditioned taste aversion, conditioned eyeblink, olfactory discrimination, social recognition, passive avoidance, schedule controlled operant tasks, motor learning, attention Feeding and drinking : daily consumption, restricted access, choice tests, microstructural analysis Reproductive behaviors : sexual and parental behaviors Social behaviors : social interaction, nesting, grooming, juvenile play, aggression Emotional behaviors : animal models of psychiatric disorders : mouse models of fear, anxiety, depression, schizophrenia Reward : self-administration of addictive drugs, conditioned place preference Neurodevelopment and neurodegeneration : assaying behaviours in infant, juvenile, and aged mice Putting it all together : choice of tests, order of testing, number of mice, equipment, housing and testing environment The next generation : conditional and inducible mutations, viral vector gene delivery, RNA silencing, quantitative trait loci analysis, DNA microarrays, chemical mutagenesis, gene therapy, ethical issues.続きを見る |
所蔵情報
| 状態 | 巻次 | 所蔵場所 | 請求記号 | 刷年 | 文庫名称 | 資料番号 | コメント | 予約・取寄 | 複写申込 | 自動書庫 |
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医学図 1F 開架図書 | QY 60/C 911/2007 | 2007 |
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042212007001153 |
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書誌詳細
| 一般注記 | Includes bibliographical references and index |
|---|---|
| 著者標目 | *Crawley, Jacqueline N. |
| 件 名 | LCSH:Neurogenetics -- Animal models
全ての件名で検索
LCSH:Transgenic mice -- Behavior 全ての件名で検索 MESH:Mice, Transgenic MESH:Behavior, Animal MESH:Disease Models, Animal MESH:Genetics, Behavioral -- methods 全ての件名で検索 MESH:Mice, Knockout MESH:Phenotype |
| 分 類 | LCC:QP356.22 NLM:QY 60.R6 DC22:573.8/480724 |
| 書誌ID | 1001330949 |
| ISBN | 9780471471929 |
| NCID | BA84237946 |
| 巻冊次 | ISBN:9780471471929 |
| 登録日 | 2009.09.18 |
| 更新日 | 2017.10.03 |