Mendeley出力
＜図書＞
DNA, words, and models
| 責任表示 | Stéphane Robin, François Rodolphe, Sophie Schbath |
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| データ種別 | 図書 |
| 出版情報 | Cambridge : Cambridge University Press , 2005 |
| 本文言語 | 英語 |
| 大きさ | xx, 138p. : ill. ; 24 cm |
| 概要 | An important problem in computational biology is identifying short DNA sequences (mathematically, 'words') associated with a biological function. One approach consists of determining whether a particu...ar word is simply random or is of statistical significance, for example, because of its frequency or location. This book introduces the mathematical and statistical ideas used in solving this so-called exceptional word problem. It begins with a detailed description of the principal models used in sequence analysis: Markovian models are central here and capture compositional information on the sequence being analysed. There follows an introduction to several statistical methods that are used for finding exceptional words with respect to the model used. The second half of the book is illustrated with numerous examples provided from the analysis of bacterial genomes, making this a practical guide for users facing a real situation and needing to make an adequate procedure choice. Book jacket.続きを見る |
| 目次 | Introduction. The context Randomness and models A bit of biology Simple models for biological sequences. Why a model? Permutation model Bernoulli model Introduction to Markov chain models. Assumptions Markov chain order 1 Markov chain order m Estimation of the parameters Taking heterogeneities into account. Phased chains Piecewise homogeneous Markov chains Translation conditional models Statistical properties of word occurrences. Count Positions and distances Distribution along the sequence Words with unexpected frequencies. Exact distribution and approximations Influence of the model Over-representations of Chi sites in E. coli and H. influenzae Under-representation of palindromes of length 6 in E. coli and in the phage Lambda Words with unexpected locations. Chi sites in the genome of H. influenzae Distribution of palindromes in E. coli's genome Detection of promoter sites in B. subtilis The last word.続きを見る |
所蔵情報
| 状態 | 巻次 | 所蔵場所 | 請求記号 | 刷年 | 文庫名称 | 資料番号 | コメント | 予約・取寄 | 複写申込 | 自動書庫 |
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hbk. | 理系図3F 数理独自 | ROBI/12/1 | 2005 |
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023212005004698 |
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hbk. | シ情情報学[BZ15] | 467/R 53 | 2005 |
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026212009000040 |
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書誌詳細
| 別書名 | 原タイトル:ADN, mots, et modéles |
|---|---|
| 一般注記 | Includes bibliographical references and index Original edition: ADN, mots et modèles ; first published in 2003 by Editions Belin |
| 著者標目 | *Robin, Stéphane, 1965- Rodolphe, François Schbath, Sophie, 1969- |
| 件 名 | LCSH:Genetics -- Mathematical models
全ての件名で検索
LCSH:Markov processes |
| 分 類 | LCC:QH438.4.M3 DC22:572.8/633 |
| 書誌ID | 1001242024 |
| ISBN | 052184729X |
| NCID | BA73967980 |
| 巻冊次 | hbk. ; ISBN:052184729X |
| 登録日 | 2009.09.18 |
| 更新日 | 2009.11.02 |