Central control mechanisms of calcium homeostasis and its physiological significance

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Central control mechanisms of calcium homeostasis and its physiological significance

Format:
Grant
Kyushu Univ. Production Kyushu Univ. Production
Title(Other Language):
環境ストレスにおける中枢性カルシウム代謝調節機構の役割
Responsibility:
粟生 修司(九州大学・大学院・医学研究院・助教授)
AOU Shuji(九州大学・大学院・医学研究院・助教授)
Language:
Japanese
Project Year:
1998-2000
Latest Report:
1) Calcium is deeply involved in adaptive control of behaviors and relevant homeostatic function during environmental changes. One of the calcium regulating brain loci, the lateral hypothalamic area, produce orexins. Orexin-A suppressed spatial learning and long-term potentiation, while facilitated avoidance learning. The peptide showed analgesic action. 2) Endogenous sugar acid 2-buten-4-olide, a satiety substance, facilitated the spatial memory. The pretreatment of acidic fibroblast growth factor antibody eliminated the effect of 2-buten-4-olide both during the training sessions and the probe test. 3) Cholecystokinin (CCK) is one of the potent hypocalcemic factor. CCK-A receptor gene deficient Otsuka Long Evans Tokushima Fatty (OLETF) rats showed spatial memory deficits and abnormal emotionality. Active fragment of aFGF improved the performance of the spatial memory task in OLETF rats. 4) The leptin receptor deficient animals, Zucker rats and db/db/mice who have abnormality in bone metabolism, showed impaired LTP and spatial memory. 5) Bisphenol A and tributyltin induced a disruption of the sexual differentiation in the locus coeruleus and learning behavior without affecting the reproductive function into the lateral hypothalamic area also induced hypokalemia which was blocked by nadrol and ranitidine. These findings strongly suggest that the hypothalamus play an important role in adaptive control of not only calcium metabolism and other visceral functions but also learning, memory and emotion. Read more
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