Knockout mouse - Its characteristics and application (1) : NMDA receptor subunit knockout mozcse

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Knockout mouse - Its characteristics and application (1) : NMDA receptor subunit knockout mozcse

Format:
Article
Kyushu Univ. Production Kyushu Univ. Production
Title(Other Language):
ノックアウトマウスーその特性と応用-(1) : NMDA受容体 サブユニットノックアウトマウス
Responsibility:
伊藤, 功(九州大学理学部生物学教室生体物理化学講座)
Ito, Isao(Faculty of Sciences, Department of Biology, Kyushu University)
Language:
Japanese
Publication info:
日本神経精神薬理学雑誌. 17, (5), pp. 185-192, 1997-05. Japanese Society of Neuropsychopharmacology
Version:
Publisher
Abstract:
The N-methyl-D-aspartate (NMDA) type of glutamate receptors is thought to be essential in many central actions of neurotransmitter glutamate, including learning, memory, neurodevelopment and neurodegenerative disorders. Recent molecular cloning has revealed that the NMDA receptor has multiple subunits with distinct distribution, properties and regulation. This implies that NMDA receptors are different in molecular architecture and functional properties, depending on the brain region and developmental stage. To clarify the significance of the molecular diversity of NMDA receptors in vivo, a gene-targeting technique was applied to NMDA receptor subunit genes and several strains of mutant mice lacking targeted NMDA receptor subunit molecules were created. Using these NMDA receptor subunit knockout mice, ivarious physiological, histological and behavioral analyses were performed. ln this article, after bridfly reviewing recent findings, we discuss the advantages and disadvantages of the NMDA receptor subunit knockout mouse as a tool for the studies of NMDA receptors and synaptic plasticity. Read more
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