Right Isomerism of the Brain in Inversus Viscerum Mutant Mice

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Right Isomerism of the Brain in Inversus Viscerum Mutant Mice

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Kyushu Univ. Production Kyushu Univ. Production
Responsibility:
Kawakami, Ryosuke(Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan | Division of Cerebral Structure, National Institute for Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies)
Dobi, Alice(Division of Cerebral Structure, National Institute for Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies)
Shigemoto, Ryuichi(Solution-Oriented Research for Science and Technology, Japan Science and Technology Agency | Division of Cerebral Structure, National Institute for Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies)

Ito, Isao(Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan)
川上, 良介(九州大学大学院理学研究院生物科学部門 | 自然科学研究機構生理学研究所)
重本, 隆一(科学技術振興機構 | 自然科学研究機構生理学研究所)
伊藤, 功(九州大学大学院理学研究院生物科学部門)

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Language:
English
Publication info:
PLoS ONE. 4, (3), pp. e1945-, 2008-04-16. Public Library of Science
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Abstract:
Left-right (L-R) asymmetry is a fundamental feature of higher-order neural function. However, the molecular basis of brain asymmetry remains unclear. We recently reported L-R asymmetry of hippocampal circuitry caused by differential allocation of N-methyl-D-aspartate receptor (NMDAR) subunit GluRε2 (NR2B) in hippocampal synapses. Using electrophysiology and immunocytochemistry, here we analyzed the hippocampal circuitry of the inversus viscerum (iv) mouse that has a randomized laterality of internal organs. The iv mouse hippocampus lacks L-R asymmetry, it exhibits right isomerism in the synaptic distribution of the ε2 subunit, irrespective of the laterality of visceral organs. This independent right isomerism of the hippocampus is the first evidence that a distinct mechanism downstream of the iv mutation generates brain asymmetry. Read more
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