Left−Right Asymmetry Defect in the Hippocampal Circuitry Impairs Spatial Learning and Working Memory in iv Mice

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Left−Right Asymmetry Defect in the Hippocampal Circuitry Impairs Spatial Learning and Working Memory in iv Mice

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Kyushu Univ. Production Kyushu Univ. Production
Responsibility:
Goto, Kazuhiro(Japan Society for the Promotion of Science)
Kurashima, Ryo(Faculty of Letters, Department of Psychology, Keio University)
Gokan, Hayato(Faculty of Letters, Department of Psychology, Keio University)

Inoue, Naomi(Faculty of Letters, Department of Psychology, Keio University)
Ito, Isao(Faculty of Sciences, Department of Biology, Kyushu University)
Watanabe, Shigeru
後藤, 和宏(京都大学大学院医学研究科附属脳機能総合研究センター)
倉嶋, 涼(慶應義塾大学文学部心理学教室)
後閑, 勇人(慶應義塾大学文学部心理学教室)
井上, 奈保美(慶應義塾大学文学部心理学教室)
伊藤, 功(九州大学大学院理学研究院生物科学部門)
渡辺, 茂(慶應義塾大学文学部心理学教室)

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Language:
English
Publication info:
PLoS ONE. 5, (11), 2010-11-17. Public Library of Science
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Publisher
Abstract:
Although left-right (L−R) asymmetry is a fundamental feature of higher-order brain function, little is known about how asymmetry defects of the brain affect animal behavior. Previously, we identified structural and functional asymmetries in the circuitry of the mouse hippocampus resulting from the asymmetrical distribution of NMDA receptor GluR ε2 (NR2B) subunits. We further examined the ε2 asymmetry in the inversus viscerum (iv) mouse, which has randomized laterality of internal organs, and found that the iv mouse hippocampus exhibits right isomerism (bilateral right-sidedness) in the synaptic distribution of the ε2 subunit, irrespective of the laterality of visceral organs. To investigate the effects of hippocampal laterality defects on higher-order brain functions, we examined the capacity of reference and working memories of iv mice using a dry maze and a delayed nonmatching-to-position (DNMTP) task, respectively. The iv mice improved dry maze performance more slowly than control mice during acquisition, whereas the asymptotic level of performance was similar between the two groups. In the DNMTP task, the iv mice showed poorer accuracy than control mice as the retention interval became longer. These results suggest that the L−R asymmetry of hippocampal circuitry is critical for the acquisition of reference memory and the retention of working memory. Read more
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