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The Pangenome : Diversity, Dynamics and Evolution of Genomes
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| 概要 | This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompa...sses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.続きを見る |
| 目次 | Part 1: Genomic diversity and the pan-genome concept Chapter 1: The pan-genome: a data-drivendiscovery in biology Chapter 2: The prokaryotic species concept and challenges Chapter 3: Bacterial guide on how to design a diversified gene portfolio Chapter 4: A review of pan-genome tools and recent studies Part 2: Evolutionary biology of pan-genomes Chapter 5: Structure and dynamics of bacterial populations: pan-genome ecology Chapter 6: Bacterial microevolution and the pan-genome Chapter 7: Pan-genomes and selection: the public goods hypothesis Chapter 8: A pan-genomic perspective on the emergence, maintenance and predictability of antibiotic resistance Part 3: Pan-genomics: an open, evolving discipline Chapter 9: Metapangenome: at the crossroad of pangenomics and metagenomics Chapter 10: Pan-genome flux balance analysis towards pan-phenomes Chapter 11: Bacterial epigenomics: epigenetics in the age of population genomics Chapter 12: Eukaryotic pan-genomes Chapter 13: Computational strategies for eukaryotic pan-genome analyses.続きを見る |
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SpringerLink eBooks Fully Open Access: 2020 OAPEN (Open Access Publishing in European Networks): 2020 DOAB Directory of Open Access Books: 2020 |
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| 登録日 | 2023.09.29 |
| 更新日 | 2024.01.30 |