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その他
Kyushu Univ. Production 九州大学成果文献
Cover image of 磁石のナノテクノロジー : 自動車からスパコンまで
湯浅, 裕美 ; Yuasa, Hiromi
出版情報: 先端サマーセミナー. 2015, 2015-08-05.
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その他
Kyushu Univ. Production 九州大学成果文献
Cover image of しなやかでかしこい電力供給・エネルギーマネジメントシステム : 効率的な電力使用と再生可能エネルギーの活用を目指して
村田, 純一 ; Murata, Junichi
出版情報: 先端サマーセミナー. 2015, 2015-08-05.
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その他
Kyushu Univ. Production 九州大学成果文献
Cover image of 認知と行動 : 安全運転を科学する
志堂寺, 和則 ; Shidoji, Kazunori
出版情報: 先端サマーセミナー. 2015, 2015-08-05.
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その他
Kyushu Univ. Production 九州大学成果文献
Cover image of グローバルな沿革医療システムの構築に向けて
アハメッド, アシル ; Ahamed, Ashir
出版情報: 先端サマーセミナー. 2015, 2015-08-05.
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雑誌論文
Kyushu Univ. Production 九州大学成果文献
Cover image of 油症における抗SS-A/Ro抗体および抗SS-B/La抗体の検討 — Anti-SSA/Ro and Anti-SSB/La Antibodies in Patients with Yusho
辻, 博 ; Tsuji, Hiroshi
出版情報: 福岡醫學雜誌. 106, (5), pp. 119-123, 2015-05-25. 福岡医学会
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概要: To investigate chronic immune effects of polychlorinated biphenyl (PCB) and polychlorinated dibenzofuran (PCDF), anti-SSA/Ro and anti-SSB/La antibodies were studied in serum of 213 patients with Yusho and 63 control subjects in 2013. Anti-SSA/Ro antibodies were found in 4.2% (9/213) of patients with Yusho and 1.6% (1/63) of control subjects. The prevalence rates of anti-SSA/Ro antibodies in Yusho patients were not associated with blood PCB concentration or blood 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) concentration. Anti-SSB/La antibodies were found in 1.4% (3/213) of patients of Yusho, but none of controls. Furthermore, high concentrations of PCB and 2,3,4,7,8-PeCDF were present in Yusho patients with anti-SSB/La antibodies. We conclude that anti-SSB/La antibody is present in patients with Yusho, and it may be associated with PCB and 2,3,4,7,8-PeCDF in the blood. 続きを見る
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雑誌論文
Kyushu Univ. Production 九州大学成果文献
Cover image of 長崎県油症患者における制御性T細胞(Treg細胞)の検討 — Serum Levels of Regulatory T Cell in the Yusho Patients
峯, 嘉子; Mine, Yoshiko; 鍬塚, 大 ... [ほか]
出版情報: 福岡醫學雜誌. 106, (5), pp. 124-126, 2015-05-25. 福岡医学会
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概要: Dioxin and dioxin-like compounds receptor (Ahr) mainly expressed on the surface of regulatory T (Treg) cell and Th17 cell could regulate immunological functions in the Yusho patients. We prospectively analyzed data obtained in a total of 56 cases of Yusho, which include patients identified ('Nintei') or non-identified ('Minintei') or identified as a family member, at the annual health check in 2014. The number of Treg cell showed lower among identified patients compared with non-identified group or family identified group (p = 0.4184 and p= 0.291, respectively). There was also a strong correlation between serum levels of neutral fat and the number of Treg cells (p=0.0313). These results suggest that Treg cell plays a principal role in the immune response among Yusho patients. 続きを見る
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雑誌論文
Kyushu Univ. Production 九州大学成果文献
Cover image of ダイオキシン母体曝露による発達児の甲状腺ホルモンへの影響 — The Effect of Maternal Exposure to Dioxins on the Level of Thyroid Hormone in Developing Pups
服部, 友紀子; Hattori, Yukiko; 武田, 知起 ... [ほか]
出版情報: 福岡醫學雜誌. 106, (5), pp. 127-134, 2015-05-25. 福岡医学会
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概要: Maternal exposure to dioxins causes a number of developmental disorders in the offspring. Previous studies have suggested that lactational exposure to 2,3,7,8-tetrachlorodizenzo-p-dioxin (TCDD) reduces the pup level of thyroid hormone after weaning, leading to the damage to their development including neural maturation. However, the specificity for age and dioxin congeners as well as dose dependency in terms of a reduction in pup thyroid hormone remains to be clarified. To address this issue, we investigated whether TCDD or 2,3,4,7,8-pentachlorodibenzofuran (PenCDF), one of the dioxins which caused 'Yusho' incident, affects the status of thyroid hormone during the fetal and neonatal periods. Treating pregnant rats at gestational day (GD) 15 with 1μg/kg TCDD scarcely affected the serum concentration of thyroxine, although a significant reduction by TCDD was detected at limited endpoints [GD21 and postnatal day (PND) 21]. In addition, maternal exposure to TCDD (0.05-30μg/kg) or PenCDF (1-1,000μg/kg) did not have any change in the serum level of thyroxine in GD20 fetuses even at the maximum dose. Neither the expression of pituitary thyroid-stimulating hormone β (TSHβ) nor hypothalamic thyrotropin-releasing hormone was sensitive to TCDD treatment. In pregnant dams, TCDD decreased the serum level of thyroxine at GD20 and 21, while the pituitary expression of TSHβ was induced. These results suggest that a single administration of dioxins to pregnant rats at GD15 have little effect on the level of thyroxine in the fetuses and infants, while a reduced level of this hormone observed in the offspring at GD21 and PND21 and pregnant dams at GD20 and 21. 続きを見る
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雑誌論文
Kyushu Univ. Production 九州大学成果文献
Cover image of 油症検診における骨密度の解析 — Bone Mineral Density in Yusho Health Examination
福士, 純一; Fukushi, Jun-ichi; Fukushi, Junichi ... [ほか]
出版情報: 福岡醫學雜誌. 106, (5), pp. 135-138, 2015-05-25. 福岡医学会
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概要: We examined the bone mineral density in Yusho patients. 460 subjects underwent dual-energy Xray absorptiometry bone scans as part of the nationwide Yusho health examination in 2011. Serum levels of polychlorinated dibenzo-p-dioxin, polychlorinated dibenzofurans, and non-ortho polychlorinated biphenyls were measured using high-resolution gas chromatography and high-resolution mass spectrometry. The average age was 64.0 years in women and 63.4 in men. About one-third (35%) of women (n=89) had low bone mineral density (BMD), defined as a T-score less than 70, while only 4.9% of men (n=10) had low BMD. Serum levels of several congeners were positively associated with Z-scores in simple regression analysis. Further multivariate linear regression analysis should be required in the future. 続きを見る
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雑誌論文
Kyushu Univ. Production 九州大学成果文献
Cover image of カネミ油症患者のダイオキシン類の半減期と芳香族炭化水素受容体(AhR)のSNPの関係 — Relationships between Half-Lives of Dioxins and SNPs in AhR among Yusho Patients
松本, 伸哉; Matsumoto, Shinya; 赤羽, 学 ... [ほか]
出版情報: 福岡醫學雜誌. 106, (5), pp. 139-143, 2015-05-25. 福岡医学会
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概要: Half-lives of blood levels of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) are varied in Yusho patients. The objective was to evaluate a relationship between half-lives of PeCDF levels and types of SNP rs10249788 of aryl hydrocarbon receptor (AHR) gene in 93 Yusho patients. Based on physical symptoms, age, sex, body mass index and other factors, we set up suitable calculation formulas to fit the actual PeCDF levels thorough rates of change in PeCDF.We found that patients with C/T SNP had longer half lives than patients with C/C and T/T SNPs. Patients with T/T SNP are known to express higher amount of AHR mRNAs. However, detailed analysis could not be carried out in T/T group due to a limited number of patients (n=11). Further research is warranted to determine the cause of the longer half-lives in C/T patients. 続きを見る
10.
図書
Kyushu Univ. Production 九州大学成果文献
Cover image of 興国寺城跡・長浜城跡の保存と服部先生
鈴木, 裕篤
出版情報: 歴史を歩く時代を歩く : 服部英雄退職記念誌 : とことん服部英雄. pp. 289-293, 2015-03-31. 九州大学大学院比較社会文化研究院服部英雄研究室
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