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The aim of this study is to investigate the significance of the sodium (Na), potassium (K), calcium (Ca) and magnesium (Mg) intake on the genesis of hypertension in five different areas in Nepal. A to...tal of 1,115 men and 1,152 women (20-85 years) were recruited for this study from five different areas; i.e. hilly villagers (Kotyang: 206 men, 212 women), suburban villagers (Bhadrakali: 265, 244), Tibetan immigrants (Jawalakhel: 242, 306) and mountain villagers (Mustang: 229, 212 and Helambu: 173, 178). Similar medica1, nutritional and anthropometrical procedures were performed on each group. The blood pressure (BP) was measured using a semiautomated device. The 24-h urinary Na and K excretions were calculated using a simple method developed by us. The 24-h urinary Ca and Mg excretions were estimated using the predicted 24-h creatinine values. A forward stepwise multiple linear regression analysis was used for the statistical method to assess the relationship of seven variables (age, BMI, sex, and urinary Na, K, Ca and Mg excretions) with the systolic and diastolic BP. The prevalence of hypertension ranged from 0 to 47% in 5 areas, and was found to be the lowest in Kotyang and the highest in Helambu. The daily salt consumption was estimated to be between 12 and 15g. The systolic BP and/or diastolic BP were significantly and positively associated with age, BMI, urinary Na and Ca excretions, while a significantly negative correlation was observed for the urinary K and Mg based on a multiple regression analysis. These results suggest that, in addition to the age and the body composition, not only the salt intake, but the intakes of K, Mg and Ca as well may also contribute to the genesis of hypertension in Nepalese inhabitants.
1987年以来続けてきているネパール健康科学調査の中から，生活環境や食生活に特徴のある5地区の20歳以上の健康な住民2,267名を対象に，高血圧関連要因としてのミネラル(Na・K・Ca・Mg)摂取量の意義を明らかにすることを目的として，簡便法を用いた尿中排泄量から推定したミネラル摂取量を主体に，血圧との関わりを重回帰分析を用いて検討した。各地区の調査はすべて同一方法で行い，各々の検査はほとんど同じ検者が担当した。1)高血圧の頻度は0%から47%まで地区によって著しい差がみられた。2)1日食塩摂取量は12〜15gで，著しい地域差はなかった。3)肥満度，身体活動量には地域差がみられた。4)血圧には，年齢・肥満度に加えて尿中Na排泄量が強く正に関わっていた。5)また血圧には尿中Ca排泄量が正に，尿中Mg排泄量は負に関わっており，その比(Ca/Mg)は血圧と正に関わっていた。6)尿中K排泄量は血圧に強く負に関わっている地域もあったが，全体でみるとそれほど強い関わりは認められなかった。今後，高血圧の非薬物療法あるいはlifestyle modificationの中で，高血圧とミネラルの関わり，すなわち食生活は益々重要視されていくと思われる。続きを見る
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Mendeley出力
