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The cross-sectional association of blood pressure with urinary sodium and potassium excretion was investigated in 1,599 subjects living in Takashima Island during the 5-year period from 1984 till 1988... in the same method and in the same season (between the end of July and the beginning of August). The subjects were 704 men, age 25 to 93 years (average age: 51+-13 years), and 895 women. 22 to 87 years (53+-13). Out of the 1,599 subjects, 1.006 (62.9%) were normotensives. 313 (19.6%) borderline hypertensives and the remainders (280; 17.5%) hypertensives according to WHO's criteria. Hypertensives included the subjects receiving antihypertensive drugs. Both systolic and diastolic blood pressure significantly increased with age in both men and women. Twenty-four hour urinary sodium and potassium excretions were estimated by the predictive equations which we developed. The subjects trying to reduce the salt intake revealed significantly lower sodium excretion in urine than those not doing so in both sexes. The subjects taking antihypertensive drugs also revealed significantly lower sodium excretion in urine than either normotensives or untreated hypertensives. Weak but significant positive correlations were detected between the blood pressure and urinary sodium or urinary Na/K ratio after age was adjusted. Positive correlation coefficients became greater when the subjects taking antihypertensive drugs and those intending to reduce the salt intake were excluded. The present study confirmed a positive within-population relationship between blood pressure and sodium excretion or urinary Na/K ratio, and suggested that the antihypertensive drug and the understanding for salt restriction should be considered when relationship between blood pressure and salt intake is discussed.続きを見る
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