The effect of several reductones such as enediol, enaminol and thiolenol compounds on growth of tumor cell was investigated using mice inplanted with sarcoma 180. The growth of tumor cell was retarded to some extent by TR, TR-Gly, TR-Leu, MHC or HQNAC. However, the activity was not observed concerning AsA-3-P in which enediol group had been blocked, suggesting the function might be attributed to the reductone structure. Amino reductones including ScA, TR-Met, TR-Phe and TR-Trp exhibited few inhibitory potentiality to tumor cell. Melanoidin containing reductone structure was prepared from chlorogenic acid by the action of apple polyphenol oxidase. Both melanoidin and chlorogenic acid inhibited the growth of tumor cell.
Mendeley出力
