A typical marine teleost, a sea bream Pagrus major, survived without visible symptoms of disease in 40% sea water, throughout the period of the experiment of a month after a short period of acclimation in 80% and 60% sea water. The osmotic pressure of the serum markedly dropped for a few days in the beginning of the period in 40% sea water, and then recovered and maintained almost the normal level (Fig. 4). Increased excretion of water by enlarged renal corpuscles (Figs. 5, 6 and 9) is considered to greatly contribute to the regulation of the osmotic pressure of the internal environment and survival in the diluted sea water. The density of the renal corpuscles also seems to increase in the diluted environment.