TheThe sequences and fluctuations in the intensity of the response of the endometrium to estrogen and progestin during lactation in the mouse were studied. Using the thickness of the endometrial edema as criteria, changes of the level of estrogen in the blood were estimated. By the response to progesterone that consists in hypertrophy of the stromal nuclei, progestin levels in the blood were estimated. High levels of estrogen concentration are seen in the first and second day of lactation, though after that estrogen levels fall. In the latter half of lactation output of estrogen are ascending gradually. However, the second coming of estrus in lactating mice appears at the end of lactation and at that time abundant output of estrogen takes place suddenly. Production of progestin is ascending gradually after parturition and the highest level of progestin is seen between 4th and 9th day of lactation. After that, progestin levels in the blood decline slowly. The stromal nuclei having received the effect of progesterone are again affected by the treatment of progesterone, whether it is endogenous or exogenous. In the end of lactation deciduomata were produced by progesterone administration in the mouse uterus.
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