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<図書>
Dopaminergic neuron transplantation in the weaver mouse model of Parkinson's disease

責任表示 by Lazaros C. Triarhou
シリーズ Advances in experimental medicine and biology ; v. 517
データ種別 図書
出版者 New York : Kluwer Academic/Plenum Publishers
出版者 Georgetown, Tex. : Landes Bioscience
出版年 c2002
本文言語 英語
大きさ x, 148 p. : ill. ; 26 cm
概要 This book is the culmination of fifteen years of research on the transplantation of dopaminergic neurons in the striatum of the weaver mouse (wv/wv), a neurological mutant characterized by geneticall...-determined degeneration of midbrain dopamine neurons. This mutant constitutes the only available laboratory model with a chronic disorder that mimics Parkinson's disease. Structural and functional aspects of intrastriatal mesencephalic neuron grafting into the weaver model are reviewed, including histochemical correlates of graft survival and integration, numerical aspects of donor cell survival, ultrastructural findings on synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor related molecules, levels of striatal amino acid receptors, and behavioural effects of unilateral and bilateral neuronal transplantations. 続きを見る

所蔵情報


医学図2F 洋雑誌 雑誌書架 2002
042242003900290

書誌詳細

一般注記 Includes bibliographical references and index
著者標目 *Triarhou, Lazaros Constantinos, 1957-
件 名 LCSH:Parkinson's disease
LCSH:Dopaminergic neurons -- Transplantation  全ての件名で検索
LCSH:Parkinson's disease -- Surgery  全ての件名で検索
MESH:Parkinson Disease -- surgery  全ての件名で検索
MESH:Neurons -- transplantation  全ての件名で検索
MESH:Brain Tissue Transplantation
MESH:Models, Neurological
MESH:Mice, Neurologic Mutant
分 類 LCC:RC382
NLM:W1
NLM:WL 359
DC21:617.4/810592
書誌ID 1001097557
ISBN 0306474352
NCID BA62073663
巻冊次 ISBN:0306474352 ; XISBN:0306474182
登録日 2009.09.17
更新日 2009.09.17

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