1. 
Article
Kyushu Univ. Production

服部, 英雄 ; Hattori, Hideo
Table of Contents:


2. 
Article
Kyushu Univ. Production

Hsieh, YingHen; Wu, Jianhong; Fang, Jian ... [et al.]


3. 
Article
Kyushu Univ. Production

浦島, 充佳 ; Urashima, Mitsuyoshi


4. 
Article
Kyushu Univ. Production

小泉, 吉輝; Koizumi, Yoshiki; 岩見, 真吾 ... [et al.]
Abstract:
The combination of drugs is a common practice for enhancing the efficiency of drug treatment and reducing the risk of emergence of drug resistance. However, selection of the optimal combination and the optimal doses remain poorly understood. Here we tried to find an optimal drug combination among four kinds of antiHCV drugs (IFNα, telaprevir, cyclosporine, and halopemide) based on mathematical model which describes HCV replication in Huh7 cells.
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5. 
Article
Kyushu Univ. Production

門脇, 弾; Kadowaki, Hazumu; 蒔田, 浩平 ... [et al.]
Abstract:
In Japan, rabies had been eradicated in 1956 and Japan has been one of the rabies free countries since then. The success of rabies eradication depended heavily on the control measure, the Act of Rabies Prevention, which includes vaccination for dogs, registration of dogs, elimination of stray dogs and quarantine of animals. However, being free from rabies for a long time made Japanese public interest in prophylaxes weakened, and it is said that the number of registered dog is largely different from the actual number and that vaccination coverage is below 40%. Moreover, the risk of transmission of rabies in Japan might be different from the past because of the change of social situation such as relationship between dogs and humans, and urbanized environment. Under such circumstances, a study on the review of current rabies prevention measure in Japan was granted by the Japan Ministry of Health, Labor and Welfares. The purposes of our study are prediction of the rabies transmission dynamics in present situation, given the disease is introduced in Japan, and the assessment of cost and efficacy of different options of preventive measures.
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6. 
Article
Kyushu Univ. Production

野口, 和久; Noguchi, Kazuhisa; 廣瀬, 英雄 ... [et al.]
Abstract:
The conventional SIR models given by the ordinary differential equations can be solved as an initial value problem. The solution may be obtained deterministically if the initial values are appropriately provided. However, disease spread phenomena show randomness. It would be more natural to deal with such equations incorporating stochastic terms. In this note, we discuss the modeling for such stochastic differential equations adapted to the SIR models
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7. 
Article
Kyushu Univ. Production

Lin, HsienHo
Abstract:
Tuberculosis (TB) remains a major infectious disease in the world, with estimated eight million incident cases every year. In the past few decades, dynamic transmission models of infectious diseases have been used increasingly to inform policy making in TB control. In this talk I will give some examples on the application of infectious disease models in TB control.
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8. 
Article
Kyushu Univ. Production

八島, 健太; Yashima, Kenta; 佐々木顕 ... [et al.]
Abstract:
Identification of highrisk community is essential for a policymaking of efficient and effective disease intervention strategies. Under the limited resources for countermeasures (e.g. stocks of vaccine and antiviral drugs) and need to minimize the economic effect of quarantine (e.g. shut down of factories and offices), it is inevitable to apply intervention strategies from higher risk areas, in order to prevent a disease invasion and to reduce the prevalence in case of pandemic. In this study we show that the sensitivity analysis of basic reproduction ratio R_0 is useful for determining the degree of risk for each area within a metropolitan area. Here we have used the actual commuter flow of Tokyo metropolitan area as an example (commuting data is acquired from the Urban Transportation Census). The model of contagious disease spread in the Tokyo metropolitan area is formulated as a metapopulation model, where each node corresponds to each local station (about 1,500 stations) and recurrent movements of commuters (about 150,000 individuals in census sample) interconnect the nodes. For an infection dynamics we assume influenza like diseases and set epidemiological state of each individual to one of Susceptible, Infectious and Recovered state (SIR model). Using this model we calculate the basic reproduction ratio R_0 using the next generation matrix method. By applying a sensitivity analysis to R_0 and calculate the effect of changing the susceptible population structure (i.e. corresponding to vaccination or isolation), we are able to rank all residential stations and commuting pathways according to its epidemiological risk. From this we compare three strategies: applying countermeasures from the top ranking, low ranking and randomly regardless of ranking. The results show that this epidemiological risk ranking according to the sensitivity analysis is very effective in preventing the spread of infectious disease.
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9. 
Article
Kyushu Univ. Production

浦島, 充佳 ; Urashima, Mitsuyoshi


10. 
Article
Kyushu Univ. Production

小泉, 吉輝; Koizumi, Yoshiki; 岩見, 真吾 ... [et al.]
Abstract:
The combination of drugs is a common practice for enhancing the efficiency of drug treatment and reducing the risk of emergence of drug resistance. However, selection of the optimal combination and the optimal doses remain poorly understood. Here we tried to find an optimal drug combination among four kinds of antiHCV drugs (IFNα, telaprevir, cyclosporine, and halopemide) based on mathematical model which describes HCV replication in Huh7 cells.
…
Read more
